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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1974 2
1975 6
1976 10
1977 11
1978 11
1979 15
1980 15
1981 14
1982 19
1983 12
1984 24
1985 17
1986 42
1987 18
1988 20
1989 19
1990 36
1991 31
1992 13
1993 18
1994 15
1995 16
1996 27
1997 12
1998 13
1999 16
2000 16
2001 10
2002 14
2003 9
2004 14
2005 13
2006 13
2007 8
2008 10
2009 14
2010 12
2011 14
2012 6
2013 10
2014 7
2015 10
2016 7
2017 5
2018 16
2019 8
2020 5
2021 6
2022 12
2023 3
2024 2

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670 results

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Page 1
Cytotoxic activity of 2-Fluoro-ara-AMP and 2-Fluoro-ara-AMP-loaded erythrocytes against human breast carcinoma cell lines.
Pierigè F, De Marco C, Orlotti N, Dominici S, Biagiotti S, Serafini S, Zaffaroni N, Magnani M, Rossi L. Pierigè F, et al. Int J Oncol. 2010 Jul;37(1):133-42. doi: 10.3892/ijo_00000661. Int J Oncol. 2010. PMID: 20514405
Fludarabine phosphate (2-Fluoro-ara-AMP) is a purine analogue approved for the clinical treatment of haematological malignancies. ...This result suggests the possibility of administering 2-Fluoro-ara-AMP in patients with breast cancer using auto …
Fludarabine phosphate (2-Fluoro-ara-AMP) is a purine analogue approved for the clinical treatment of haematological mal …
Activity of 2-fluoro-Ara AMP against gynecologic tumors in the soft agar assay.
Ajani JA, Tomasovic B, Spitzer G, Kavanagh JJ, Thielvoldt D, Baker FL, Gershenson D. Ajani JA, et al. Invest New Drugs. 1986;4(2):141-8. doi: 10.1007/BF00194593. Invest New Drugs. 1986. PMID: 2426218
Tumors were exposed continuously to three different concentrations of each drug. 2-fluoro-Ara AMP was tested against 26 tumors, cisplatin against 24, and doxorubicin against 14. ...Five of six (83%) specimens demonstrated cross-sensitivity between cisplatin and 2-fl …
Tumors were exposed continuously to three different concentrations of each drug. 2-fluoro-Ara AMP was tested against 26 tumors …
Metabolism and action of fludarabine phosphate.
Plunkett W, Huang P, Gandhi V. Plunkett W, et al. Semin Oncol. 1990 Oct;17(5 Suppl 8):3-17. Semin Oncol. 1990. PMID: 1699280 Review.
That action is potentiated by the decrease of cellular dATP that results from inhibition of ribonucleotide reductase by F-ara-ATP. In vitro experiments demonstrated that DNA polymerase delta is able to excise the incorporated F-ara-AMP residues from DNA with …
That action is potentiated by the decrease of cellular dATP that results from inhibition of ribonucleotide reductase by F-ara-ATP. In …
Phase I study of fludarabine (2-fluoro-ara-AMP).
Kavanagh JJ, Krakoff IH, Bodey GP. Kavanagh JJ, et al. Eur J Cancer Clin Oncol. 1985 Sep;21(9):1009-11. doi: 10.1016/0277-5379(85)90283-4. Eur J Cancer Clin Oncol. 1985. PMID: 2415365
Fludarabine phosphate is a derivative of adenosine arabinoside. The compound is an antimetabolite which resists deamination by the addition of a phosphate moiety. ...
Fludarabine phosphate is a derivative of adenosine arabinoside. The compound is an antimetabolite which resists deamination by the ad …
Encapsulation, metabolism and release of 2-fluoro-ara-AMP from human erythrocytes.
Fraternale A, Rossi L, Magnani M. Fraternale A, et al. Biochim Biophys Acta. 1996 Oct 24;1291(2):149-54. doi: 10.1016/0304-4165(96)00059-1. Biochim Biophys Acta. 1996. PMID: 8898876
2-Fluoro-ara-AMP (fludarabine phosphate) is a purine analogue with anti-neoplastic activity in lymphoproliferative malignancies. ...The apparent Km for fludarabine monophosphate in the phosphorylation reaction was 0.4 mM and the Vmax 40 nmol/min per g hemoglo …
2-Fluoro-ara-AMP (fludarabine phosphate) is a purine analogue with anti-neoplastic activity in lymphoproliferative mali …
Ara AMP- a highly soluble new antiviral drug.
Pavan-Langston D, North RD, Geary PA. Pavan-Langston D, et al. Ann Ophthalmol. 1976 May;8(5):571-9. Ann Ophthalmol. 1976. PMID: 937940
The monophosphate ester or vidarabine, Ara AMP, however, is metabolized very slowly in humans and is extremely soluble with good tissue penetrance. The present study indicates that Ara AMP drops are equipotent or superior to vidarabine oi …
The monophosphate ester or vidarabine, Ara AMP, however, is metabolized very slowly in humans and is extremely soluble …
5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis.
Zhao J, Liu Q, Yi D, Li Q, Guo S, Ma L, Zhang Y, Dong D, Guo F, Liu Z, Wei T, Li X, Cen S. Zhao J, et al. Antiviral Res. 2022 Feb;198:105254. doi: 10.1016/j.antiviral.2022.105254. Epub 2022 Jan 29. Antiviral Res. 2022. PMID: 35101534 Free PMC article.
In this study, using our previously developed cell-based SARS-CoV-2 RdRp report system, we screened 134 compounds in the Selleckchemicals NAs library. Four candidate compounds, Fludarabine Phosphate, Fludarabine, 6-Thio-20-Deoxyguanosine (6-Thio-dG), and 5-Iodotubercidin, …
In this study, using our previously developed cell-based SARS-CoV-2 RdRp report system, we screened 134 compounds in the Selleckchemicals NA …
Phase I clinical trial of fludarabine phosphate (F-ara-AMP).
Casper ES, Mittelman A, Kelson D, Young CW. Casper ES, et al. Cancer Chemother Pharmacol. 1985;15(3):233-5. doi: 10.1007/BF00263892. Cancer Chemother Pharmacol. 1985. PMID: 2414021
F-Ara-AMP (fludarabine phosphate) is an adenosine analogue that is resistant to deamination; it is a more potent cytotoxic compound than ara-A in experimental tumor systems. F-Ara-AMP was given by continuous IV infusion over 5 days once e …
F-Ara-AMP (fludarabine phosphate) is an adenosine analogue that is resistant to deamination; it is a more potent cytoto …
Inhibition of salvage pathway enzymes by adenine arabinoside 5'-monophosphate (ara-AMP).
Becher HJ, Schollmeyer P. Becher HJ, et al. Klin Wochenschr. 1983 Aug 1;61(15):751-7. doi: 10.1007/BF01497402. Klin Wochenschr. 1983. PMID: 6194338
The effect of 9-beta-arabinofuranosyladenine 5'-monophosphate (ara-AMP) on the purine salvage pathway has been studied. On a dose-dependent basis ara-AMP inhibits the incorporation of adenine-8-14C into nucleotides in intact erythrocytes. The partially …
The effect of 9-beta-arabinofuranosyladenine 5'-monophosphate (ara-AMP) on the purine salvage pathway has been studied. On a d …
670 results